TONSL

Name

tonsoku like, DNA repair protein

Type

protein-coding

Position

144,428,763–144,444,488 (−)

Aliases

IKBR, NFKBIL2, SEMDSP

Ensembl

ENSG00000160949

RefSeq RNA

NM_013432.5, XM_011517048.3, XM_011517049.3, XM_011517050.3, XM_054360512.1

RefSeq protein

NP_038460.4, XP_011515350.1, XP_011515351.1, XP_011515352.1, XP_054216487.1

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

tonsoku like, DNA repair protein

Symbol

TONSL

Biotype

Protein coding

Organism

Homo sapiens

Location

8:144,428,763-144,444,488

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0