TONSL
Sign in to saveAlso known as IKBR, NFKBIL2, tonsoku-like, DNA repair protein, tonsoku like, DNA repair protein, SEMDSP
gene da espécie Homo sapiens
Gene data
TONSL- Name
- tonsoku like, DNA repair protein
- Type
- protein-coding
- Position
- 144,428,763–144,444,488 (−)
- Aliases
- IKBR, NFKBIL2, SEMDSP
- Ensembl
- ENSG00000160949
- RefSeq RNA
- NM_013432.5, XM_011517048.3, XM_011517049.3, XM_011517050.3, XM_054360512.1
- RefSeq protein
- NP_038460.4, XP_011515350.1, XP_011515351.1, XP_011515352.1, XP_054216487.1
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
double-strand break repair via homologous recombinationdouble-strand break repair via homologous recombinationdouble-strand break repair via homologous recombinationchromatin organizationreplication fork processingreplication fork processingreplication fork processingprotein localization to chromatin
Molecular function
via MyGene.info
Gene · Ensembl
tonsoku like, DNA repair protein
- Symbol
- TONSL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:144,428,763-144,444,488
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 22754
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4796
- chromosome
- human chromosome 8
- genomic start
- 145654165
- genomic end
- 144444440
- cytogenetic location
- 8q24.3
- expressed in
- body of stomach
Sources (6)
via Wikidata · CC0