TREM2
Sign in to saveAlso known as TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
gene umano
Gene data
TREM2- Name
- triggering receptor expressed on myeloid cells 2
- Type
- protein-coding
- Position
- 41,158,488–41,163,203 (−)
- Aliases
- AD17, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
- Ensembl
- ENSG00000095970
- RefSeq RNA
- NM_001271821.2, NM_018965.4
- RefSeq protein
- NP_001258750.1, NP_061838.1
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
triggering receptor expressed on myeloid cells 2
- Symbol
- TREM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,158,488-41,163,203
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10352
- genetic association
- Nasu-Hakola disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/54209
- genomic end
- 41130924
- genomic start
- 41126244
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.1
Sources (7)
via Wikidata · CC0