TREML1

Also known as GLTL1825, PRO3438, TLT-1, TLT1, dJ238O23.3, triggering receptor expressed on myeloid cells like 1

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.

Gene data

TREML1

Name: triggering receptor expressed on myeloid cells like 1
Type: protein-coding
Position: 41,149,167–41,155,556 (−)
Aliases: GLTL1825, PRO3438, TLT-1, TLT1, dJ238O23.3
Ensembl: ENSG00000161911
RefSeq RNA: NM_001271807.1, NM_001271808.1, NM_178174.4, XM_017010822.2, XM_017010823.2
RefSeq protein: NP_001258736.1, NP_001258737.1, NP_835468.1, XP_016866311.1, XP_016866312.1

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012].

Gene Ontology

Biological process

signal transduction calcium-mediated signaling platelet activation platelet activation platelet activation innate immune response

Molecular function

transmembrane signaling receptor activity protein binding

Cellular component

cytoplasm cytoplasm cytosol plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane

Pathways

Adaptive Immune System Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Gene · Ensembl

triggering receptor expressed on myeloid cells like 1

Symbol: TREML1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:41,149,167-41,155,556
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

2 sections

Contents

References
Further reading

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.

Excerpted from Wikipedia’s “TREML1” article, available under the CC BY-SA 4.0 licence.

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