CD33 molecule
Sign in to saveAlso known as Siglec-3, myeloid cell surface antigen CD33, gp67, CD33 antigen (gp67), CD33, CD33 molecule transcript, sialic acid-binding Ig-like lectin 3
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
Research
503 papers- Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.ACS medicinal chemistry letters · 2022
- CD33 BiTE(®) molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.Cancer immunology, immunotherapy : CII · 2023
- CAR-T cell therapy in AML: recent progress and future perspectives.International journal of hematology · 2024
- CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML.Blood · 2025
- Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.iScience · 2019
via PubMed
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Article
6 sectionsContents
- Structure
- Function
- Alzheimer's disease
- Clinical significance
- References
- External links
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
It binds sialic acids, therefore is a member of the SIGLEC family of lectins.