tremelimumab
Sign in to saveAlso known as TICILIMUMAB, CP-675206, CP-675,206
Tremelimumab, sold under the brand name Imjudo, is a fully human monoclonal antibody used for the treatment of hepatocellular carcinoma (a type of liver cancer). Tremelimumab is designed to attach to and block CTLA-4, a protein that controls the activity of T cells, which are part of the immune system (the body’s natural defenses).
Research
883 papers- Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma.NEJM evidence · 2022
- Tremelimumab.2012
- Tremelimumab: First Approval.Drugs · 2023
- Durvalumab With or Without Tremelimumab in Combination With Chemotherapy as First-Line Therapy for Metastatic Non-Small-Cell Lung Cancer: The Phase III POSEIDON Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
- Tremelimumab.2006
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has use
- medication
Show 2 more facts
- World Health Organisation international non-proprietary name
- tremelimumab
- subject has role
- monoclonal antibody
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Mechanism of action
- History
- Clinical trials
- Melanoma
- Mesothelioma
- Non-small cell lung cancer
- Society and culture
- Legal status
- Names
- References
Tremelimumab, sold under the brand name Imjudo, is a fully human monoclonal antibody used for the treatment of hepatocellular carcinoma (a type of liver cancer). Tremelimumab is designed to attach to and block CTLA-4, a protein that controls the activity of T cells, which are part of the immune system (the body’s natural defenses).
The most common side effects when used in combination with durvalumab include rash, pruritus (itching), diarrhea, abdominal (belly) pain, increased levels of liver enzymes, fever, hypothyroidism (an underactive thyroid gland), cough, peripheral edema (swelling especially of the ankles and feet) and increased level of lipase (an enzyme that helps digest fat, mainly made in the pancreas).
Excerpted from Wikipedia’s “tremelimumab” article, available under the CC BY-SA 4.0 licence.