triamcinolone hexacetonide

Chemical data

Formula

C30H41FO7

Molecular weight

532.6 g/mol

IUPAC name

[2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 3,3-dimethylbutanoate

SMILES

C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)COC(=O)CC(C)(C)C)CCC5=CC(=O)C=C[C@@]53C)F)O

InChIKey

TZIZWYVVGLXXFV-FLRHRWPCSA-N

XLogP

4.8

Polar surface area

99.1 Ų

H-bond donors

1

H-bond acceptors

8

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1969

Admin. routes

parenteral

Indications

pain, rheumatoid arthritis, joint disease, osteoarthritis

via ChEMBL · EBI

• Data evaluating triamcinolone acetonide and triamcinolone hexacetonide loaded poly(δ-valerolactone-co-allyl-δ-valerolactone) microparticles.Data in brief · 2023
• Inflammatory arthritis or osteoarthritis of the knee - Efficacy of intra-joint infiltration of methylprednisolone acetate versus triamcinolone acetonide or triamcinolone hexacetonide.Revista da Associacao Medica Brasileira (1992) · 2017
• Comparison of efficacy between triamcinolone acetonide and triamcinolone hexacetonide for intraarticular therapy in juvenile idiopathic arthritis: a retrospective analysis.BMC rheumatology · 2022
• Elimination profile of triamcinolone hexacetonide and its metabolites in human urine and plasma after a single intra-articular administration.Drug testing and analysis · 2019
• Pharmacology of intra-articular triamcinolone.Inflammopharmacology · 2014

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

532.284

via Wikidata · CC0