Structure via PubChem · Public domain (PubChem)
trichostatin A
Sign in to saveAlso known as TSA, 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide
chemical compound
Chemical data
- Formula
- C17H22N2O3
- Molecular weight
- 302.37 g/mol
- IUPAC name
- (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
- SMILES
- C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- InChIKey
- RTKIYFITIVXBLE-QEQCGCAPSA-N
- XLogP
- 2.7
- Polar surface area
- 69.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 1
- Molecule type
- Small molecule
- Indications
- cancer
via ChEMBL · EBI
Research
5,330 papers- Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase.Biochemistry · 2023
- Trichostatin A mitigates radiation-induced teratogenesis in C57Bl/6 mice.Mutagenesis · 2021
- Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function.BioEssays : news and reviews in molecular, cellular and developmental biology · 1995
- Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells.The CRISPR journal · 2023
- HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes.Aging · 2021
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 302.163
Show 5 more facts
- chemical formula
- C₁₇H₂₂N₂O₃
- Commons category
- Trichostatin A
- canonical SMILES
- CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- isomeric SMILES
- C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- subject has role
- antifungal
via Wikidata · CC0