givinostat
Sign in to saveAlso known as gavinostat, ITF-2357, ITF2357, {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate
Givinostat, sold under the brand name Duvyzat is a medication used for the treatment of Duchenne muscular dystrophy. It is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a histone deacetylase (HDAC) inhibitor that works by targeting pathogenic processes to reduce inflammation and loss of muscle.
Wikidata facts
- Subclass of
- angiogenesis inhibitor
- Mass
- 421.200156
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₄H₂₇N₃O₄
- canonical SMILES
- CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO
- inhibitor of
- growth
- route of administration
- oral administration
- World Health Organisation international non-proprietary name
- givinostatum
Sources (2)
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Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- History
- Society and culture
- Legal status
- Names
- Research
- References
- Further reading
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451563965 | image = Givinostat structure.svg | image_class = skin-invert-image | alt = | width = | caption =
| pronounce = | tradename = Duvyzat | Drugs.com = | MedlinePlus = a624025 | DailyMedID = Givinostat | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = Histone deacetylase inhibitor | ATC_prefix = M09 | ATC_suffix = AX14 | ATC_supplemental =
Excerpted from Wikipedia’s “givinostat” article, available under the CC BY-SA 4.0 licence.