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Sign in to saveSwainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of economic losses in livestock industries, particularly in North America. It was first isolated from Swainsona canescens.
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9 sectionsContents
- Pharmacology
- Sources
- Biosynthesis
- Synthesis
- Livestock losses
- Potential uses
- Molecular mechanism
- See also
- References
Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of economic losses in livestock industries, particularly in North America. It was first isolated from Swainsona canescens.
==Pharmacology== Swainsonine inhibits glycoside hydrolases, specifically those involved in N-linked glycosylation. Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core with processing on the 3-arm that resembles so-called complex-type glycans.
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Alkaloids found in FabaceaeChembox image size setChemical articles with multiple compound IDsECHA InfoCard ID from WikidataExperimental cancer drugsIminosugarsIndolizidine alkaloidsIndolizidinesMultiple chemicals in an infobox that need indexingPlant toxinsSecondary alcoholsSuspected female reproductive toxins