UHRF1
Sign in to saveAlso known as ICBP90, Np95, RNF106, hNP95, hUHRF1, huNp95, TDRD22, ubiquitin like with PHD and ring finger domains 1
Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. It acts as an epigenetic regulator that links DNA methylation to histone modifications and has been implicated in several key cellular processes, including DNA replication, the maintenance of DNA methylation, and the repair of DNA damage. Because it coordinates several layers of epigenetic regulation, it is considered an integrative epigenetic hub. The gene is overexpressed in numerous cancer types, making it a potential therapeutic target. Several transcri
Gene data
UHRF1- Name
- ubiquitin like with PHD and ring finger domains 1
- Type
- protein-coding
- Aliases
- ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014].
via MyGene.info
Wikidata facts
- Image
- Protein UHRF1 PDB 2faz.png
Show 5 more facts
- HomoloGene ID
- 7866
- exact match
- identifiers.org/ncbigene/29128
- genomic end
- 4962154
- genomic start
- 4903080
- cytogenetic location
- 19p13.3
Sources (4)
via Wikidata · CC0
~15 min read
Article
9 sectionsContents
- Structure
- Subcellular location
- Function
- Post-translational modifications for UHRF1 gene
- Clinical significance
- Role in cancer
- UHRF1 as a therapeutic target in cancer
- References
- Further reading
Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. It acts as an epigenetic regulator that links DNA methylation to histone modifications and has been implicated in several key cellular processes, including DNA replication, the maintenance of DNA methylation, and the repair of DNA damage. Because it coordinates several layers of epigenetic regulation, it is considered an integrative epigenetic hub. The gene is overexpressed in numerous cancer types, making it a potential therapeutic target. Several transcript variants encoding distinct isoforms have been identified, and a related pseudogene is present on chromosome 12.
== Structure == UHRF1 has five conserved domains; a ubiquitin-like domain (UBL), a tandem tudor domain (TTD), a plant homeodomain (PHD), a SET and RING associated (SRA) domain, and a Really Interesting New Gene (RING) domain.