Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. It acts as an epigenetic regulator that links DNA methylation to histone modifications and has been implicated in several key cellular processes, including DNA replication, the maintenance of DNA methylation, and the repair of DNA damage. Because it coordinates several layers of epigenetic regulation, it is considered an integrative epigenetic hub. The gene is overexpressed in numerous cancer types, making it a potential therapeutic target. Several transcri
Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. It acts as an epigenetic regulator that links DNA methylation to histone modifications and has been implicated in several key cellular processes, including DNA replication, the maintenance of DNA methylation, and the repair of DNA damage. Because it coordinates several layers of epigenetic regulation, it is considered an integrative epigenetic hub. The gene is overexpressed in numerous cancer types, making it a potential therapeutic target. Several transcript variants encoding distinct isoforms have been identified, and a related pseudogene is present on chromosome 12.
== Structure == UHRF1 has five conserved domains; a ubiquitin-like domain (UBL), a tandem tudor domain (TTD), a plant homeodomain (PHD), a SET and RING associated (SRA) domain, and a Really Interesting New Gene (RING) domain.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).