epigenetics
Sign in to savethumb|Epigenetic mechanisms
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Article
46 sectionsContents
- Definitions
- Waddington's canalisation, 1940s
- Contemporary
- Mechanisms
- DNA methylation
- RNA methylation
- Histone modifications
- RNA transcripts
- MicroRNAs
- sRNAs
- Long non-coding RNAs
- Prions
- Molecular basis
- DNA damage
- DNA repair
- Repair of oxidative DNA damage can alter epigenetic markers
- Homologous recombinational repair alters epigenetic markers
- Non-homologous end joining can cause some epigenetic marker alterations
- Structural inheritance
- Nucleosome positioning
- Histone variants
- Genomic architecture
- Functions and consequences
- In the brain
- Memory
- Aging
- Other and general
- Development
- Transgenerational
- Epigenetics in bacteria
- Medicine
- Twins
- Genomic imprinting
- Examples of drugs altering gene expression from epigenetic events
- Addiction
- Research
- Epigenome editing
- CpG sites, SNPs and biological traits
- ''UBASH3B'' locus
- ''NFKBIE'' locus
- ''FADS1'' locus
- Pseudoscience
- See also
- References
- Further reading
- External links
thumb|Epigenetic mechanisms
Epigenetics is the study of changes in gene expression that occur without altering the DNA sequence. The Greek prefix epi- (ἐπι- "over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional DNA-sequence-based mechanism of inheritance. Epigenetics usually involves changes that persist through cell division, and affect the regulation of gene expression. Such effects on cellular and physiological traits may result from environmental factors, or be part of normal development.