UNC13B
Sign in to saveAlso known as MUNC13, UNC13, Unc13h2, unc-13 homolog B (C. elegans), unc-13 homolog B, munc13-2
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene and in mice by the Munc13-2 gene
Gene data
UNC13B- Name
- unc-13 homolog B
- Type
- protein-coding
- Position
- 35,161,829–35,405,339 (+)
- Aliases
- MUNC13, UNC13, Unc13h2, munc13-2
- Ensembl
- ENSG00000198722
- RefSeq RNA
- NM_001330653.3, NM_001371186.2, NM_001371187.2, NM_001371188.2, NM_001371189.2
- RefSeq protein
- NP_001317582.1, NP_001358115.1, NP_001358116.1, NP_001358117.1, NP_001358118.1
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
unc-13 homolog B
- Symbol
- UNC13B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:35,161,829-35,405,339
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene and in mice by the Munc13-2 gene
== Function ==
Excerpted from Wikipedia’s “UNC13B” article, available under the CC BY-SA 4.0 licence.