STX1A

Also known as HPC-1, P35-1, STX1, SYN1A, syntaxin 1A

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

Gene data

STX1A

Name: syntaxin 1A
Type: protein-coding
Position: 73,699,205–73,719,691 (−)
Aliases: HPC-1, P35-1, STX1, SYN1A
Ensembl: ENSG00000106089
RefSeq RNA: NM_001165903.2, NM_004603.4, XM_047420777.1, XM_047420778.1, XM_054358896.1
RefSeq protein: NP_001159375.1, NP_004594.1, XP_047276733.1, XP_047276734.1, XP_054214871.1

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

Pathways

SNARE interactions in vesicular transport - Homo sapiens (human)Synaptic vesicle cycle - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Huntington disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Amphetamine addiction - Homo sapiens (human)Neurotransmitter release cycle Transmission across Chemical Synapses Neuronal System Neuronal System

via MyGene.info

Gene · Ensembl

syntaxin 1A

Symbol: STX1A
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:73,699,205-73,719,706
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Three-dimensional structure of the complexin SNARE complex - Syntaxin-1A 1KIL.png

Show 5 more facts

HomoloGene ID: 37941
exact match: identifiers.org/ncbigene/6804
genomic start: 73113536
genomic end: 73134002
cytogenetic location: 7q11.23

Sources (6)

via Wikidata · CC0

~2 min read

Article

8 sections

Contents

Function
Clinical significance
Interactive pathway map
Interactions
See also
References
Further reading
External links

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

== Function == Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.