UPF1

Also known as HUPF1, NORF1, RENT1, pNORF1, smg-2, UPF1, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF

Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene.

Gene data

UPF1

Name: UPF1 RNA helicase and ATPase
Type: protein-coding
Position: 18,831,905–18,868,232 (+)
Aliases: HUPF1, NORF1, RENT1, UTF, pNORF1, smg-2
Ensembl: ENSG00000005007
RefSeq RNA: NM_001297549.2, NM_002911.4, XM_017027105.3, XM_017027106.3, XM_047439191.1
RefSeq protein: NP_001284478.1, NP_002902.2, XP_016882594.1, XP_016882595.1, XP_047295147.1

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].