Skip to content
Vinony
English
EnglishDeutschEspañolFrançaisItalianoNederlandsPortuguêsSvenskaالعربية
GeneQ18042066· pop 5· linked from 38 articles

DCP1A

Sign in to save

Also known as HSA275986, Nbla00360, SMAD4IP1, SMIF, decapping mRNA 1A

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.

Gene data

DCP1A
Name
decapping mRNA 1A
Type
protein-coding
Position
53,283,429–53,347,683 (−)
Aliases
HSA275986, Nbla00360, SMAD4IP1, SMIF
Ensembl
ENSG00000272886
RefSeq RNA
NM_001290204.2, NM_001290205.2, NM_001290206.2, NM_001290207.2, NM_018403.7
RefSeq protein
NP_001277133.1, NP_001277134.1, NP_001277135.1, NP_001277136.1, NP_060873.4

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].

Gene Ontology

Pathways

RNA degradation - Homo sapiens (human)Deadenylation-dependent mRNA decaymRNA decay by 5' to 3' exoribonucleaseButyrate Response Factor 1 (BRF1) binds and destabilizes mRNATristetraprolin (TTP, ZFP36) binds and destabilizes mRNARegulation of mRNA stability by proteins that bind AU-rich elementsMetabolism of RNANonsense-Mediated Decay (NMD)Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TGF-beta Signaling Pathway

via MyGene.info

Gene · Ensembl

decapping mRNA 1A

Symbol
DCP1A
Biotype
Protein coding
Organism
Homo sapiens
Location
3:53,283,429-53,347,683
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
10178
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/55802
chromosome
human chromosome 3
genomic start
53283429
genomic end
53347586
cytogenetic location
3p21.1
expressed in
islet of Langerhans
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • Interactions
  • References
  • Further reading

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.

Excerpted from Wikipedia’s “DCP1A” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0