virotherapy
Sign in to saveVirotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy. These branches use three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery. Gene overexpression adds genetic sequences that compensate for low to zero levels of needed gene expression. Gene knockout uses RNA methods to silence or reduce expression of disease-causing genes. Suicide g
Key facts
- Medical intervention.name
- Virotherapy
- Medical intervention.specialty
- virology
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Article
22 sectionsContents
- History
- Oncolytic virotherapy
- Mechanism
- Clinical development
- Approved for clinical use
- Others
- Challenges and future prospective
- Viral gene therapy
- Mechanism
- Clinical development
- Approved for clinical use
- Adeno-associated virus
- Chimeric antigen receptor T cells
- Others
- Challenges and future prospective
- Viral immunotherapy
- Cancer treatment
- Other projects and products
- Protozoal virotherapy
- See also
- References
- Further reading
Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy. These branches use three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery. Gene overexpression adds genetic sequences that compensate for low to zero levels of needed gene expression. Gene knockout uses RNA methods to silence or reduce expression of disease-causing genes. Suicide gene delivery introduces genetic sequences that induce an apoptotic response in cells, usually to kill cancerous growths. In a slightly different context, virotherapy can also refer more broadly to the use of viruses to treat certain medical conditions by killing pathogens.
==History== Chester M. Southam, a researcher at Memorial Sloan Kettering Cancer Center, pioneered the study of viruses as potential agents to treat cancer.