Orthopoxvirus
Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and reptiles, and arthropods serve as natural hosts. There are 12 known species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and mpox. The most widely known member of the genus is Variola virus, which causes smallpox. It was eradicated globally by 1977, through the use of Vaccinia virus as a vaccine. The most recently described species is the Borealpox virus, first isolated in 2015.
Species
GENUS
- KingdomViruses
- PhylumNucleocytoviricota
- ClassPokkesviricetes
- OrderChitovirales
- FamilyPoxviridae
via GBIF
Research
16,633 papers- Orthopoxvirus diagnostics.Methods in molecular biology (Clifton, N.J.) · 2004
- A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease.Cell · 2024
- Neurological complications of Orthopoxvirus infections: neurotropism and neurovirulence.Brain : a journal of neurology · 2025
Article
16 sectionsContents
- Microbiology
- Structure
- Genome
- Lifecycle
- Transmission
- Distribution
- Taxonomy
- Evolution
- Infection in humans
- Zoonoses
- Laboratory transmission
- Signs and symptoms
- Treatment
- Lab synthesis
- References
- External links
Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and reptiles, and arthropods serve as natural hosts. There are 12 known species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and mpox. The most widely known member of the genus is Variola virus, which causes smallpox. It was eradicated globally by 1977, through the use of Vaccinia virus as a vaccine. The most recently described species is the Borealpox virus, first isolated in 2015.
== Microbiology == ===Structure=== thumb|Schematic drawing of (cross section) of Orthopoxvirus virions (one enveloped, one not) and [[structural proteins]] Orthopoxviruses are enveloped with brick-shaped geometries and virion dimensions around 200 nm wide and 250 nm long.