Structure via PubChem · Public domain (PubChem)
wogonin
Sign in to saveAlso known as Norwogonin 8-methyl ether, 5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one, 5,7-Dihydroxy-8-methoxyflavone
Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.
Chemical data
- Formula
- C16H12O5
- Molecular weight
- 284.26 g/mol
- IUPAC name
- 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
- SMILES
- COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O
- InChIKey
- XLTFNNCXVBYBSX-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 76 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,352 papers- Wogonin Attenuates Atherosclerosis via KLF11-Mediated Suppression of PPARα-YAP1-Driven Glycolysis and Enhancement of ABCA1/G1-Mediated Cholesterol Efflux.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
- Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis.Acta pharmacologica Sinica · 2025
- Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease.Acta pharmacologica Sinica · 2022
- Wogonin improves colitis by activating the AhR pathway to regulate the plasticity of ILC3/ILC1.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
- Wogonin mitigates acetaminophen-induced liver injury in mice through inhibition of the PI3K/AKT signaling pathway.Journal of ethnopharmacology · 2024
via PubMed
Wikidata facts
- Subclass of
- flavone
- Mass
- 284.068473
Show 4 more facts
- found in taxon
- Aria edulis
- canonical SMILES
- COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O
- chemical formula
- C₁₆H₁₂O₅
- Commons category
- Wogonin
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Pharmacology
- See also
- References
Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.
The glycosides of wogonin are known as wogonosides. For example, oroxindin is a wogonin glucuronide isolated from Oroxylum indicum. It is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement.
Excerpted from Wikipedia’s “wogonin” article, available under the CC BY-SA 4.0 licence.