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GeneQ8041712· pop 5· linked from 195 articles

XCL2

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Also known as SCM-1b, SCM1B, SCYC2, chemokine (C motif) ligand 2, X-C motif chemokine ligand 2

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1. It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. Its gene is located on chromosome 1 in humans.

Gene data

XCL2
Name
X-C motif chemokine ligand 2
Type
protein-coding
Position
168,540,765–168,544,113 (−)
Aliases
SCM-1b, SCM1B, SCYC2
Ensembl
ENSG00000143185
RefSeq RNA
NM_003175.4
RefSeq protein
NP_003166.1

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptorsChemokine receptors bind chemokinesGPCR downstream signallingG alpha (q) signalling events

via MyGene.info

Gene · Ensembl

X-C motif chemokine ligand 2

Symbol
XCL2
Biotype
Protein coding
Organism
Homo sapiens
Location
1:168,540,765-168,544,113
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

1 sections
Contents
  • References

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1. It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. Its gene is located on chromosome 1 in humans.

==References==

Excerpted from Wikipedia’s “XCL2” article, available under the CC BY-SA 4.0 licence.

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