YAF2

Also known as YY1 associated factor 2

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

Gene data

YAF2

Name: YY1 associated factor 2
Type: protein-coding
Position: 42,157,104–42,238,349 (−)
Ensembl: ENSG00000015153
RefSeq RNA: NM_001012424.1, NM_001190977.3, NM_001190979.3, NM_001190980.3, NM_001320080.2
RefSeq protein: NP_001177906.1, NP_001177908.1, NP_001177909.1, NP_001307009.1, NP_005739.2

This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016].

Gene Ontology

Biological process

regulation of DNA-templated transcription heterochromatin formation negative regulation of DNA-templated transcription negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription

Molecular function

DNA binding transcription coregulator activity transcription coactivator activity transcription corepressor activity protein binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Generic Transcription Pathway RNA Polymerase II Transcription Gene expression (Transcription)Transcriptional regulation by RUNX1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6

via MyGene.info

Wikidata facts

Image: Protein YAF2 PDB 2d9g.png

Show 5 more facts

HomoloGene ID: 136401
exact match: identifiers.org/ncbigene/10138
genomic end: 42632151
genomic start: 42550906
cytogenetic location: 12q12

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YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.