Deoxyribonucleases

Cas9 (CRISPR-associated protein 9, formerly Cas5, Csn1, or Csx12) is a DNA cutting enzyme that is part of the CRISPR immune system in bacteria and archaea. It has been adapted to be used as a CRISPR genome editing tool that enables targeted modification of DNA sequences and permanently changes a cell’s genome.

Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. The role of the DNase enzyme in cells includes breaking down extracellular DNA (ecDNA) excreted by apoptosis, necrosis, and neutrophil extracellular traps (NET) of cells to help reduce inflammatory responses that otherwise are elicited. A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, che

protein-coding gene in the species Homo sapiens

endonuclease

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene. It is also known as DNaseX due to its localisation on the X chromosome.

Exodeoxyribonucleases are both exonucleases and deoxyribonucleases. They catalyze digestion of the ends of linear DNA. They are a type of esterase. They are classified EC 3.1.11.