DNASE1

Also known as DNL1, DRNI, deoxyribonuclease I, deoxyribonuclease 1, Deoxyribonuclease I, deoxyribonuclease-1, DNase I

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, DNASE1 is referenced by 474 other articles, and connects out to PubMed, deoxyribonucleic acid and enzyme.

Vinony files it under Deoxyribonucleases, EC 3.1.21 and Genes on human chromosome 16.

Its subject is documented across 11 Wikipedia language editions.

Gene data

DNASE1

Name: deoxyribonuclease 1
Type: protein-coding
Position: 3,611,678–3,680,143 (+)
Aliases: DNL1, DRNI
Ensembl: ENSG00000213918
RefSeq RNA: NM_001351825.2, NM_001387135.1, NM_001387139.1, NM_001387140.1, NM_001387141.1
RefSeq protein: NP_001338754.1, NP_001374064.1, NP_001374068.1, NP_001374069.1, NP_001374070.1

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

deoxyribonuclease 1

Symbol: DNASE1
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:3,611,678-3,680,143
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Protein · UniProt

Deoxyribonuclease-1

Gene: Dnase1
Organism: Mus musculus (Mouse)
Length: 284 aa
Molecular mass: 32,027 Da
Evidence: 1: Evidence at protein level

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:29191910). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradat…

Actin-bindingApoptosisCalciumCytoplasmic vesicleDisulfide bondEndonucleaseGlycoproteinHydrolase

View on UniProt →

Swiss-Prot (reviewed) · via UniProt