DNASE1L1

Also known as DNAS1L1, DNASEX, DNL1L, G4.8, XIB, deoxyribonuclease I-like 1, deoxyribonuclease 1 like 1

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene. It is also known as DNaseX due to its localisation on the X chromosome.

In the Vinony graph

Vinony's link graph records 5 inbound references to DNASE1L1, and connects out to PubMed, X chromosome and Ensembl genome database project.

It sits within the topics Deoxyribonucleases and Genes on human chromosome X.

Vinony links it to 5 Wikipedia language editions.

Gene data

DNASE1L1

Name: deoxyribonuclease 1 like 1
Type: protein-coding
Chromosome: X
Position: 154,401,236–154,412,119 (−)
Aliases: DNAS1L1, DNASEX, DNL1L, G4.8, XIB
Ensembl: ENSG00000013563
RefSeq RNA: NM_001009932.3, NM_001009933.3, NM_001009934.3, NM_001303620.2, NM_006730.4
RefSeq protein: NP_001009932.1, NP_001009933.1, NP_001009934.1, NP_001290549.1, NP_006721.1

This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015].

Gene Ontology

Biological process

DNA metabolic process DNA catabolic process DNA catabolic process

Molecular function

DNA binding DNA binding catalytic activity deoxyribonuclease I activity DNA nuclease activity DNA nuclease activity protein binding

Cellular component

extracellular region nucleus endoplasmic reticulum endoplasmic reticulum specific granule lumen

Pathways

Innate Immune System Immune System Neutrophil degranulation

via MyGene.info

Gene · Ensembl

deoxyribonuclease 1 like 1

Symbol: DNASE1L1
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:154,401,236-154,412,119
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 4896
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1774
chromosome: human X chromosome
genomic start: 154401236
genomic end: 153640449
cytogenetic location: Xq28

Sources (4)

via Wikidata · CC0

~4 min read

Encyclopedic overview

4 sections

Contents

Importance
Clinical application
References
Further reading

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene. It is also known as DNaseX due to its localisation on the X chromosome.

This gene encodes a member of the deoxyribonuclease family and the protein and DNA shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.

Excerpted from Wikipedia’s “DNASE1L1” article, available under the CC BY-SA 4.0 licence.