EC 3.5.4

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

The double-stranded RNA-specific adenosine deaminase enzyme family are encoded by the ADAR family genes. ADAR stands for adenosine deaminase acting on RNA. This article focuses on the ADAR proteins; This article details the evolutionary history, structure, function, mechanisms and importance of all proteins within this family.

mammalian protein found in Homo sapiens

mammalian protein found in Homo sapiens

thumb|150px|right|The general structure of an amine An aminohydrolase is a hydrolase enzyme which acts upon an amino group.

APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in innate anti-viral immunity. APOBEC3G belongs to the family of cytidine deaminases that catalyze the deamination of cytidine to uridine in the single stranded DNA substrate. The C-terminal domain of A3G renders catalytic activity, several NMR and crystal structures explain the substrate specificity and catalytic activity.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

Probable C->U-editing enzyme APOBEC-2 is a protein that in humans is encoded by the APOBEC2 gene.

class of enzymes

300px|thumb|upright|Example of a member of the APOBEC family, APOBEC-2. A cytidine deaminase from Homo sapiens.

C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene. It is primarily expressed in testis and found in mammals, chicken, but not fishes.