Adenosine deaminase

Protein · UniProt

Adenosine deaminase

Gene

ADA

Organism

Homo sapiens (Human)

Length

363 aa

Molecular mass

40,764 Da

Evidence

1: Evidence at protein level

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulator…

• PHASE1/PHASE2COMPLETED
  Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCIDUniversity of California, Los Angeles · NCT02999984
• PHASE1/PHASE2COMPLETED
  Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCIDGreat Ormond Street Hospital for Children NHS Foundation Trust · NCT03765632
• PHASE1COMPLETED
  Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow TransplantFred Hutchinson Cancer Center · NCT00008450
• PHASE1/PHASE2COMPLETED
  Autologous CD34+ Hematopoietic Stem Cells Transduced ex Vivo With Elongation Factor 1 Alpha Shortened (EFS) Lentiviral Vector Encoding for the Human ADA GeneUniversity of California, Los Angeles · NCT01852071
• UNKNOWN
  Methodology Study of Retroviral Insertion Site Analysis in Strimvelis Gene TherapyFondazione Telethon · NCT04959890
• COMPLETED
  Regulation of Vascular Thrombosis in Sleep ApneaWeill Medical College of Cornell University · NCT00859690

via ClinicalTrials.gov

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