Fc receptors

protein

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cel

mammalian protein found in Homo sapiens

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.

Fc fragment of IgA receptor (FCAR) is a human gene that codes for the transmembrane receptor FcαRI, also known as CD89 (Cluster of Differentiation 89). FcαRI binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies. FcαRI is present on the cell surface of myeloid lineage cells, including neutrophils, monocytes, macrophages, and eosinophils, though it is notably absent from intestinal macrophages and does not appear on mast cells. FcαRI plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. Inside-out signaling primes FcαRI in order for

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307 (cluster of differentiation 307).

Fc receptor-like protein 2 is a protein that in humans is encoded by the FCRL2 gene.

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.

Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes.

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes. Cellular responses regulated by CD32 include phagocytosis, cytokine stimulation, and endocytic transport. Dysregulated CD32 is associated with different forms of autoimmunity,

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.

Fc receptor-like protein 1 is a protein that in humans is encoded by the FCRL1 gene.

protein-coding gene in the species Homo sapiens

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.

Fcα/μR, also known as is CD351 (Cluster of Differentiation 351), is an Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity. In mice the receptor is expressed on macrophages, follicular dendritic cells, marginal zone B cells, follicular B cells, and kidney tubular epithelial cells. In humans expression has been described on intestinal lamina propria cells, Paneth cells, follicular dendritic cells in tonsils, activated macrophages and some types of pre-germinal centre IgD+/CD38+ B cells.

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.