MS4A2

Also known as APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

Gene data

MS4A2

Name: membrane spanning 4-domains A2
Type: protein-coding
Position: 60,088,261–60,098,467 (+)
Aliases: APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER
Ensembl: ENSG00000149534
RefSeq RNA: NM_000139.5, NM_001142303.1, NM_001256916.2, XM_005273846.5, XM_011544850.3
RefSeq protein: NP_000130.1, NP_001243845.1, XP_005273903.1, XP_011543152.1, XP_016872851.1

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012].

Gene Ontology

Biological process

immune response cell surface receptor signaling pathway

Molecular function

protein binding IgE binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane membrane Fc-epsilon receptor I complex

Pathways

Sphingolipid signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Fc epsilon RI signaling pathway - Homo sapiens (human)Asthma - Homo sapiens (human)Innate Immune System Innate Immune System Immune System Immune System Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling

via MyGene.info

Gene · Ensembl

membrane spanning 4-domains A2

Symbol: MS4A2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:60,088,261-60,098,467
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

HomoloGene ID: 112
exact match: identifiers.org/ncbigene/2206
genomic end: 60098467
genomic start: 59855734
cytogenetic location: 11q12.1
Commons category: MS4A2

Sources (4)

via Wikidata · CC0

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Article

4 sections

Contents

Function
See also
References
Further reading

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

==Function== The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.