Sulfonamide antibiotics

class of pharmaceutical drugs

Sulfadiazine is an antibiotic. Used together with pyrimethamine, a dihydrofolate reductase inhibitor, it is the treatment of choice for toxoplasmosis, which is caused by a protozoan parasite. It is a second-line treatment for otitis media, prophylaxis of rheumatic fever, chancroid, chlamydia, and infections by Haemophilus influenzae. It is also used as adjunct therapy for chloroquine-resistant malaria and several forms of bacterial meningitis. It is taken by mouth. Sulfadiazine is available in multiple generic tablets of 500 mg. For urinary tract infections, the usual dose is 4 to 6 grams

Sulfamethoxazole (SMZ or SMX) is an antibiotic. It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.

Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. Sulfanilamide is rarely if ever used systemically due to toxicity and because more effective sulfonamides are available for this purpose. Modern antibiotics have supplanted sulfanilamide on the battlefield; however, sulfanilamide remains in use

chemical compound

thumb|Pure Sulfacetamide sodium salt is a white or slightly yellow crystalline powder Sulfacetamide is a sulfonamide antibiotic commonly used in the treatment of bacterial infections, particularly those affecting the eyes and skin. It functions by inhibiting the synthesis of folic acid in bacteria, which is essential for their growth and reproduction, thereby exerting a bacteriostatic effect. Available in various forms, including eye drops, topical solutions, and creams, sulfacetamide is often prescribed for conditions such as conjunctivitis, seborrheic dermatitis, and acne vulgaris. Its effic

Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist. The discovery and development of this first sulfonamide-containing drug opened a new era in medicine, because it greatly widened the success of antimicrobial chemotherapy in an era when many physicians doubted its still largely untapped potential. At the time, disinfectant cleaners and topical antisept

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.

Sulfamethizole is a sulfonamide antibiotic.

Sulfadimidine or sulfamethazine is a sulfonamide antibacterial.

Sulfamerazine is a sulfonamide antibacterial. ==Synthesis== thumb|center|700px|Sulfamerazine synthesis:

Sulfafurazole (INN, also known as sulfisoxazole) is a sulfonamide antibacterial with a dimethyl-isoxazole substituent. It possesses antibiotic activity against a wide range of Gram-negative and Gram-positive organisms. It is sometimes given in combination with erythromycin (see erythromycin/sulfafurazole) or phenazopyridine. It is used locally in a 4% solution or ointment.

Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections and can be given as a standalone or combined with ormetoprim to broaden the target range. Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA. It is the most common drug prescribed to dogs who have coccidiosis.

Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than

Sulfathiazole is an organosulfur compound used as a short-acting sulfa drug. Formerly, it was a common oral and topical antimicrobial, until less toxic alternatives were discovered.

Sulfaguanidine is a sulfonamide.

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003), sulfamethin and sulfaisodimidine, is a sulfonamide antibacterial. It is closely related to sulfadimidine.

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria. As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.

Phthalylsulfathiazole (also known as sulfathalidine) is a sulfonamide broad-spectrum antimicrobial used primarily for treating gastrointestinal infections.

Sulfaphenazole (or sulfafenazol) is a sulfonamide antibacterial.

Sulfamoxole is a sulfonamide antibacterial.

Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.

Sulfathiourea is a sulfonamide antibacterial.

Sulfaperin (or sulfaperine) is a sulfonamide antibacterial.

Sulfametrole (INN) is a sulfonamide antibacterial.

Sulfacytine is a short-acting sulfonamide antibiotic, taken orally for treatment against bacterial infections. Sulfonamides, as a group of antibiotics, work by inhibiting the bacterial synthesis of folate. In 2006, the drug was discontinued.

Succinylsulfathiazole (also known as sulfasuxidine) is a sulfonamide. It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.

Sulfamazone (INN) is a sulfonamide antibiotic with antipyretic properties.

Sulfamethoxypyridazine is a sulfonamide antibacterial.

Sulfadicramide (marketed as Irgamid) is an anti-infective.

Sulfaquinoxaline (IUPAC name: '4-Amino-N-2-quinoxalinylbenzenesulfonamide') is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.

Improperly prepared sulfanilamide medicine that caused mass poisoning in the US in 1937

Sulfametomidine (or sulfamethomidine) is a sulfonamide antibacterial.

Sulfoxone or aldesulfone sodium is an anti-leprosy drug. It is also known as diasone. Diasone is mentioned as an anti-leprosy drug in the 1961 movie "The Devil At 4 O'clock". Sulfoxone sodium was introduced in Japan in 1948. Ernest Muir introduced it to Western use while serving as superintendent of the Chacachacare Leprosarium on Trinidad in the Caribbean.

Sulfatolamide is a drug used in gynecology. It is a combination of two sulfonamide antibacterials, sulfathiourea and mafenide.