Structure via PubChem · Public domain (PubChem)
2,2,2-trifluoroethanol
Sign in to saveAlso known as 2,2,2-trifluoroethyl alcohol, TFE, trifluoroethanol
2,2,2-Trifluoroethanol is the synthetic organic compound with the formula CF3CH2OH. Also known as TFEA or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol.
In the Vinony graph
Within Vinony's link graph, 2,2,2-trifluoroethanol is referenced by 701 other articles, and connects out to ginkgolide, picrotoxin and benzodiazepine drug.
It is catalogued under topics including Chembox having GHS data, Chembox image size set and Chemical articles with multiple compound IDs.
Its subject is documented across 20 Wikipedia language editions.
Chemical data
- Formula
- C2H3F3O
- Molecular weight
- 100.04 g/mol
- IUPAC name
- 2,2,2-trifluoroethanol
- SMILES
- C(C(F)(F)F)O
- InChIKey
- RHQDFWAXVIIEBN-UHFFFAOYSA-N
- XLogP
- 0.4
- Polar surface area
- 20.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
2,733 papers- 2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes.Archiv der Pharmazie · 2022
- 2,2,2-Trifluoroethanol toxicity in aged rats.Toxicologic pathology · 1988
- Interactions of 2,2,2-trifluoroethanol with melittin.Magnetic resonance in chemistry : MRC · 2009
- Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol.Critical reviews in toxicology · 1988
- 2,2,2-Trifluoroethanol toxicity in hamsters (Mesocricetus auratus).Toxicologic pathology · 1987
via PubMed
Wikidata facts
- Subclass of
- primary alcohol
- Has part
- carbon
- Mass
- 100.014
Show 6 more facts
- chemical formula
- C₂H₃F₃O
- pKa
- 12.37
- canonical SMILES
- C(C(F)(F)F)O
- global warming potential
- 24
- melting point
- -44
- Commons category
- 2,2,2-Trifluoroethanol
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Synthesis
- Properties
- Reactions
- Safety
- See also
- References
- External links
2,2,2-Trifluoroethanol is the synthetic organic compound with the formula CF3CH2OH. Also known as TFEA or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol.
==Synthesis== Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride.
Excerpted from Wikipedia’s “2,2,2-trifluoroethanol” article, available under the CC BY-SA 4.0 licence.