Structure via PubChem · Public domain (PubChem)
2,2,2-trifluoroethanol
Sign in to saveAlso known as 2,2,2-trifluoroethyl alcohol, TFE, trifluoroethanol
2,2,2-Trifluoroethanol is the synthetic organic compound with the formula CF3CH2OH. Also known as TFEA or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol.
Chemical data
- Formula
- C2H3F3O
- Molecular weight
- 100.04 g/mol
- IUPAC name
- 2,2,2-trifluoroethanol
- SMILES
- C(C(F)(F)F)O
- InChIKey
- RHQDFWAXVIIEBN-UHFFFAOYSA-N
- XLogP
- 0.4
- Polar surface area
- 20.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
2,733 papers- 2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes.Archiv der Pharmazie · 2022
- 2,2,2-Trifluoroethanol toxicity in aged rats.Toxicologic pathology · 1988
- Interactions of 2,2,2-trifluoroethanol with melittin.Magnetic resonance in chemistry : MRC · 2009
- Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol.Critical reviews in toxicology · 1988
- 2,2,2-Trifluoroethanol toxicity in hamsters (Mesocricetus auratus).Toxicologic pathology · 1987
via PubMed
Wikidata facts
- Subclass of
- primary alcohol
- Has part
- carbon
- Mass
- 100.014
Show 6 more facts
- chemical formula
- C₂H₃F₃O
- pKa
- 12.37
- canonical SMILES
- C(C(F)(F)F)O
- global warming potential
- 24
- melting point
- -44
- Commons category
- 2,2,2-Trifluoroethanol
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Synthesis
- Properties
- Reactions
- Safety
- See also
- References
- External links
2,2,2-Trifluoroethanol is the synthetic organic compound with the formula CF3CH2OH. Also known as TFEA or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol.
==Synthesis== Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride.
Excerpted from Wikipedia’s “2,2,2-trifluoroethanol” article, available under the CC BY-SA 4.0 licence.