5-hydroxytryptamine receptor 1A

Protein · UniProt

5-hydroxytryptamine receptor 1A

Gene

HTR1A

Organism

Homo sapiens (Human)

Length

422 aa

Molecular mass

46,107 Da

Evidence

1: Evidence at protein level

G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:…

• COMPLETED
  PET Whole Body Distribution Studies Using [11C]CUMINational Institute of Mental Health (NIMH) · NCT01132872
• EARLY_PHASE1COMPLETED
  [18F]-F13640 as a New Brain RadiopharmaceuticalHospices Civils de Lyon · NCT03347331
• PHASE2COMPLETED
  Buspirone for Early Satiety and Symptoms of GastroparesisJohns Hopkins Bloomberg School of Public Health · NCT03587142
• PHASE1/PHASE2RECRUITING
  A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)Merck Sharp & Dohme LLC · NCT07302347
• PHASE1COMPLETED
  Study Of Safety, Blood Levels, And Brain Receptor Occupancy Of GSK163090 Using PET Imaging In Healthy MalesGlaxoSmithKline · NCT00435695
• COMPLETED
  Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress DisorderNational Institute of Mental Health (NIMH) · NCT00025974

via ClinicalTrials.gov

Wikidata facts

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protein

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