ABCG5

Also known as STSL, ATP binding cassette subfamily G member 5, STSL2

ATP-binding cassette sub-family G member 5 is a protein that in humans is encoded by the ABCG5 gene.

Gene data

ABCG5

Name: ATP binding cassette subfamily G member 5
Type: protein-coding
Position: 43,812,472–43,838,865 (−)
Aliases: STSL, STSL2
Ensembl: ENSG00000138075
RefSeq RNA: NM_022436.3, XM_005264480.5, XM_006712073.4, XM_006712074.4, XM_011533024.3
RefSeq protein: NP_071881.1, XP_005264537.1, XP_006712136.1, XP_006712137.1, XP_011531326.1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].