lipoprotein lipase

Protein · UniProt

Lipoprotein lipase

Gene

LPL

Organism

Homo sapiens (Human)

Length

475 aa

Molecular mass

53,162 Da

Evidence

1: Evidence at protein level

Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:11342582, PubMed:27578112, PubMed:8675619). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (PubMed:12032167, PubMed:7592706). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:2472638…

• NO_LONGER_AVAILABLE
  Volanesorsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)Akcea Therapeutics · NCT03544060
• EARLY_PHASE1COMPLETED
  A Study in Healthy Participants Investigating Biomarkers After Exposure to Heparin When Heparin is Administered in the Fasted State or After a High-fat Meal. Heparin, a Registered Drug, is an Anticoagulant (Blood Thinner) That Prevents the Formation of Blood Clots.Novo Nordisk A/S · NCT05178550
• PHASE2COMPLETED
  Phase 2 Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Chylomicronemia Syndrome (FCS)Akcea Therapeutics · NCT03360747
• PHASE3COMPLETED
  The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia SyndromeAkcea Therapeutics · NCT02658175
• COMPLETED
  Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical AssessmentUniversity of Colorado, Denver · NCT02656095
• NACOMPLETED
  Effects of Water-Based Exercise on Lipid Profile and Lipoprotein Lipase of Dyslipidemic Premenopausal WomenHospital de Clinicas de Porto Alegre · NCT02418715

via ClinicalTrials.gov

Wikidata facts

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protein

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