Low density lipoprotein receptor
Sign in to saveAlso known as low-density lipoprotein receptor class A domain-containing protein 3, low-density lipoprotein receptor, LDL receptor, receptors, LDL, uniprot:P01130, LDLR
mammalian protein found in Homo sapiens
Protein · UniProt
Low-density lipoprotein receptor
- Gene
- LDLR
- Organism
- Homo sapiens (Human)
- Length
- 860 aa
- Molecular mass
- 95,376 Da
- Evidence
- 1: Evidence at protein level
Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021)
3D-structureAlternative splicingCell membraneCholesterol metabolismCoated pitDirect protein sequencingDisease variantDisulfide bond
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
44,603 papers- Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration.International journal of molecular sciences · 2022
- Lipoprotein receptor signalling in atherosclerosis.Cardiovascular research · 2020
- The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms.Atherosclerosis · 2025
- The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells.Nature communications · 2024
- Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease.European heart journal · 2021
via PubMed
Clinical Trials
289 registered- PHASE3COMPLETEDStudy to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial HypercholesterolemiaKastle Therapeutics, LLC · NCT00607373
- NAENROLLING_BY_INVITATIONPenn Family Screening for Familial HypercholesterolemiaNorthwestern University · NCT05750667
- PHASE3COMPLETEDRandomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying TherapiesNewAmsterdam Pharma · NCT05142722
- PHASE2COMPLETEDStudy of MGL-3196 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)Madrigal Pharmaceuticals, Inc. · NCT03038022
- PHASE3COMPLETEDA Study to Evaluate the Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial HypercholesterolemiaAstraZeneca · NCT02434497
- PHASE4TERMINATEDLong Term Safety Study of PRALUENTRegeneron Pharmaceuticals · NCT03694197
Wikidata facts
- Instance of
- protein
Show 2 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P01130
via Wikidata · CC0