Lipase C, hepatic type

Also known as lipase member C, lipase, hepatic, hepatic triacylglycerol lipase, LIPC, hepatic lipase, Triacylglycerol lipase

mammalian protein found in Homo sapiens

Protein · UniProt

Hepatic triacylglycerol lipase

Gene: LIPC
Organism: Homo sapiens (Human)
Length: 499 aa
Molecular mass: 55,914 Da
Evidence: 1: Evidence at protein level

Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:12032167, PubMed:26193433, PubMed:7592706, PubMed:8798474). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrat…

Direct protein sequencingDisease variantGlycoproteinHDLHeparin-bindingHydrolaseLipid degradationLipid metabolism

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

1 registered

NACOMPLETED
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and GlucoseTufts University · NCT02938091

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Image: LIPC protein.png

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found in taxon: Homo sapiens
cell component: extracellular space
Commons category: Hepatic lipase

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