Structure via PubChem · Public domain (PubChem)
acamprosate
Sign in to saveAlso known as Campral®, 3-Acetamido-1-propanesulfonic acid, N-Acetylhomotaurine, Acamprosato, Acamprosatum, N-acetyl homotaurine
Acamprosate, sold under the brand name Campral, is a medication which reduces cravings in alcoholism. It is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal. When used alone, acamprosate is not an effective therapy for alcohol use disorder in most individuals, as it only addresses withdrawal symptoms and not psychological dependence. It facilitates a reduction in alcohol consumption as well as full abstinence when used in combination with psychosocial support or other drugs that address the addictive behavior.
Key facts
- Drug.PubChem
- 155434
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 477237602
- Drug.image
- Acamprosate structure.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of acamprosate
- Drug.image2
- Acamprosate molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the acamprosate molecule
- Drug.JAN
- acamprosate calcium
- Drug.USAN
- acamprosate calcium
- Drug.tradename
- Campral, Campral EC
- Drug.DailyMedID
- Acamprosate
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N07
- Drug.ATC_suffix
- BB03
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C5H11NO4S
- Molecular weight
- 181.21 g/mol
- IUPAC name
- 3-acetamidopropane-1-sulfonic acid
- SMILES
- CC(=O)NCCCS(=O)(=O)O
- InChIKey
- AFCGFAGUEYAMAO-UHFFFAOYSA-N
- XLogP
- -1.2
- Polar surface area
- 91.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,141 papers- Acamprosate.Expert opinion on drug metabolism & toxicology · 2010
- Acamprosate.Drugs in R&D · 2002
- Acamprosate for alcohol dependence.The Cochrane database of systematic reviews · 2010
- Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis.JAMA · 2023
- Acamprosate.Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism · 2003
via PubMed
Wikidata facts
- Mass
- 181.041
Show 5 more facts
- Commons category
- Acamprosate
- chemical formula
- C₅H₁₁NO₄S
- isomeric SMILES
- C/C(=N/CCCS(=O)(=O)O)/O
- canonical SMILES
- CC(=O)NCCCS(=O)(=O)O
- defined daily dose
- 2
Sources (6)
via Wikidata · CC0
~11 min read
Article
17 sectionsContents
- Medical uses
- Compliance
- Contraindications
- Adverse effects
- Pharmacology
- Pharmacodynamics
- GABA/NMDA hypothesis
- mGluR hypothesis
- Calcium hypothesis
- Synergy hypothesis
- Other effects
- Pharmacokinetics
- History
- Society and culture
- Names
- Research
- References
Acamprosate, sold under the brand name Campral, is a medication which reduces cravings in alcoholism. It is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal. When used alone, acamprosate is not an effective therapy for alcohol use disorder in most individuals, as it only addresses withdrawal symptoms and not psychological dependence. It facilitates a reduction in alcohol consumption as well as full abstinence when used in combination with psychosocial support or other drugs that address the addictive behavior.
Serious side effects include allergic reactions, abnormal heart rhythms, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. Diarrhea is the most common side effect. It is unclear if use is safe during pregnancy.