Tabernanthine is an alkaloid found in Tabernanthe iboga. It has been used in laboratory experiments to study how addiction affects the brain. Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.
Tabernanthine is an alkaloid found in Tabernanthe iboga. It has been used in laboratory experiments to study how addiction affects the brain. Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.
== Pharmacology == It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptors.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).