adrenoceptor beta 2
Sign in to saveAlso known as beta-2 adrenoreceptor, catecholamine receptor, beta-2 adrenoceptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, ADRB2, beta-2 adrenergic receptor
mammalian protein found in Homo sapiens
Protein · UniProt
Beta-2 adrenergic receptor
- Gene
- ADRB2
- Organism
- Homo sapiens (Human)
- Length
- 413 aa
- Molecular mass
- 46,459 Da
- Evidence
- 1: Evidence at protein level
G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (PubMed:2831218, PubMed:33093660, PubMed:7915137). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively (By similarity). Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate (By similarity). Epi also promotes ADRB2 coupling to G(i) pro…
Swiss-Prot (reviewed) · via UniProt
Research
30,252 papers- Beta-adrenoceptor polymorphisms.Naunyn-Schmiedeberg's archives of pharmacology · 2004
- Presynaptic Adrenoceptors.Handbook of experimental pharmacology · 2024
- Alpha-adrenoceptor subtypes.Pharmacological research · 2001
- Structures of Adrenoceptors.Handbook of experimental pharmacology · 2024
- Subtype-selective modulation of human beta 1- and beta 2-adrenoceptor function by beta-adrenoceptor agonists and antagonists.Clinical physiology and biochemistry · 1990
via PubMed
Clinical Trials
18 registered- PHASE4COMPLETEDNebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of LifeWeill Medical College of Cornell University · NCT00999102
- COMPLETEDWEUKBRE5554: IMI PROTECT(Work Package 2): Beta2 Agonists and Acute Myocardial InfarctionGlaxoSmithKline · NCT01636726
- NAUNKNOWNThe Effect of Ongoing Beta-blockers Administration on Analgesic Requirements in the Immediate Perioperative Period.Tel-Aviv Sourasky Medical Center · NCT03498898
- NATERMINATEDThe Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic VariationsBrigham and Women's Hospital · NCT00706446
- NACOMPLETEDEffect of Symbicort on GR Localisation in AsthmaImperial College London · NCT00159263
- PHASE4COMPLETEDAssociation Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.Merck KGaA, Darmstadt, Germany · NCT01104558