Structure via PubChem · Public domain (PubChem)
nadolol
Sign in to saveAlso known as Corgard®, corzide, SQ-11725
Nadolol, sold under the brand name Corgard among others, is a medication used to treat high blood pressure, heart pain, atrial fibrillation, and some inherited arrhythmic syndromes. It has also been used to prevent migraine headaches and complications of cirrhosis. It is taken orally.
Chemical data
- Formula
- C17H27NO4
- Molecular weight
- 309.4 g/mol
- IUPAC name
- (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
- SMILES
- CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
- InChIKey
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N
- XLogP
- 0.7
- Polar surface area
- 82 Ų
- H-bond donors
- 4
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,478 papers- Clinical pharmacokinetics of nadolol: A systematic review.Journal of clinical pharmacy and therapeutics · 2022
- Nadolol: a new beta-adrenoceptor antagonist.The New England journal of medicine · 1981
- Green tea and nadolol interaction: A risk of therapeutic inefficiency, a case report and extensive review.Therapie · 2024
- Nadolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris.Drugs · 1980
- Nadolol in thyrotoxicosis.British journal of clinical pharmacology · 1982
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 309.194008
- Has use
- medication
Show 13 more facts
- chemical formula
- C₁₇H₂₇NO₄
- route of administration
- oral administration
- World Health Organisation international non-proprietary name
- nadolol
- medical condition treated
- arterial hypertension
- isomeric SMILES
- CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
- canonical SMILES
- CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
- defined daily dose
- 0.16
- NCI Thesaurus ID
- C29280
- subject has role
- Sympatholytic
- physically interacts with
- adrenoceptor beta 3
- significant drug interaction
- lidocaine
- legal status (medicine)
- boxed warning
- Commons category
- Nadolol
Sources (7)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- References
- External links
{{Drugbox | Watchedfields = changed | verifiedrevid = 470624569 | image = Nadolol.svg | image_class = skin-invert-image | width =
| tradename = Corgard, others | Drugs.com = | MedlinePlus = a682666 | DailyMedID = Nadolol | pregnancy_AU = | pregnancy_US = C | pregnancy_category = | legal_UK = POM | legal_US = Rx-only | legal_status = | routes_of_administration = Oral | class = Beta blocker; β-Adrenergic receptor antagonist; Non-selective β1- and β2-adrenergic receptor antagonist | ATC_prefix = C07 | ATC_suffix = AA12
Excerpted from Wikipedia’s “nadolol” article, available under the CC BY-SA 4.0 licence.