adrenomedullin
thumb|Structure of adrenomedullin Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inf
Research
4,304 papers- Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes.Science (New York, N.Y.) · 2025
- Adrenomedullin in pulmonary hypertension.Danish medical journal · 2024
- Adrenomedullin in the eye.Regulatory peptides · 2003
- Adrenomedullin as a Biomarker of Heart Failure.Heart failure clinics · 2018
- [Adrenomedullin].Nihon rinsho. Japanese journal of clinical medicine · 2011
via PubMed
Article
11 sectionsContents
- Structure
- Function
- Receptors
- Clinical significance
- Cardiovascular health
- Gastrointestinal health
- Sepsis
- Tumor angiogenesis
- References
- Further reading
- External links
thumb|Structure of adrenomedullin Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.
In humans, ADM is encoded by the ADM gene. A similar peptide named adreomedullin2 was reported in rats in 2004, which exhibits a similar function.