Fibroblast growth factor 18

Protein · UniProt

Fibroblast growth factor 18

Gene

FGF18

Organism

Homo sapiens (Human)

Length

207 aa

Molecular mass

23,989 Da

Evidence

1: Evidence at protein level

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation

• PHASE2COMPLETED
  A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the KneeEMD Serono Research & Development Institute, Inc. · NCT01919164
• PHASE1COMPLETED
  A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring SurgeryMerck KGaA, Darmstadt, Germany · NCT01033994
• PHASE2TERMINATED
  A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the KneeEMD Serono · NCT01689337
• PHASE1COMPLETED
  Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee ReplacementMerck KGaA, Darmstadt, Germany · NCT00911469
• PHASE2TERMINATED
  Sprifermin (AS902330) in Cartilage Injury Repair (CIR)Merck KGaA, Darmstadt, Germany · NCT01066871
• PHASE3COMPLETED
  A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With AchondroplasiaQED Therapeutics, a BridgeBio company · NCT06164951

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Subclass of

protein

via Wikidata · CC0