AGXT
Sign in to saveAlso known as AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase
Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.
Gene data
AGXT- Name
- alanine--glyoxylate aminotransferase
- Type
- protein-coding
- Position
- 240,868,543–240,881,531 (+)
- Aliases
- AGT, AGT1, AGXT1, PH1, SPAT, SPT, Ser-PyrAT, TLH6
- Ensembl
- ENSG00000172482
- RefSeq RNA
- NM_000030.3
- RefSeq protein
- NP_000021.1
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
alanine--glyoxylate aminotransferase
- Symbol
- AGXT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:240,868,543-240,881,531
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein AGXT PDB 1h0c.png
Show 8 more facts
- HomoloGene ID
- 37251
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/189
- genomic end
- 241819919
- genomic start
- 240868824
- chromosome
- human chromosome 2
- cytogenetic location
- 2q37.3
- expressed in
- renal cortex
via Wikidata · CC0
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Encyclopedic overview
4 sectionsContents
- See also
- References
- External links
- Further reading
Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria.
Excerpted from Wikipedia’s “AGXT” article, available under the CC BY-SA 4.0 licence.