AGXT
Sign in to saveAlso known as AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase
gene umano
Gene data
AGXT- Name
- alanine--glyoxylate aminotransferase
- Type
- protein-coding
- Position
- 240,868,543–240,881,531 (+)
- Aliases
- AGT, AGT1, AGXT1, PH1, SPAT, SPT, Ser-PyrAT, TLH6
- Ensembl
- ENSG00000172482
- RefSeq RNA
- NM_000030.3
- RefSeq protein
- NP_000021.1
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
L-serine:pyruvate transaminase activityL-serine:pyruvate transaminase activityL-serine:pyruvate transaminase activityprotein bindingL-alanine:glyoxylate transaminase activityL-alanine:glyoxylate transaminase activityL-alanine:glyoxylate transaminase activityL-alanine:glyoxylate transaminase activity
Pathways
Alanine, aspartate and glutamate metabolism - Homo sapiens (human)Glycine, serine and threonine metabolism - Homo sapiens (human)Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)Peroxisome - Homo sapiens (human)MetabolismGlyoxylate metabolism and glycine degradationMetabolism of amino acids and derivativesPeroxisomal protein importPeroxisomal protein importProtein localization
via MyGene.info
Gene · Ensembl
alanine--glyoxylate aminotransferase
- Symbol
- AGXT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:240,868,543-240,881,531
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein AGXT PDB 1h0c.png
Show 8 more facts
- HomoloGene ID
- 37251
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/189
- genomic end
- 241819919
- genomic start
- 240868824
- chromosome
- human chromosome 2
- cytogenetic location
- 2q37.3
- expressed in
- renal cortex
via Wikidata · CC0