aspartate transaminase

Also known as aspartate aminotransferase, aspartate aminotransferases, AST, SGOT, GOT, OT

class of enzymes

In the Vinony graph

Vinony's link graph records 543 inbound references to aspartate transaminase, and connects out to alpha-ketoglutaric acid, mitochondrion and transaminase.

It is catalogued under topics including EC 2.6.1, Glutamate (neurotransmitter) and Liver function tests.

Vinony links it to 30 Wikipedia language editions.

Key facts

Ec no: 2.6.1.1
Cas no: 9000-97-9
Intenz: IntEnz view
Brenda: BRENDA entry
Expasy: NiceZyme view
Kegg: KEGG entry
Metacyc: metabolic pathway
Priam: profile
Pdb structures: RCSB PDB PDBe PDBsum
Gene ontology: AmiGO / QuickGO
Pmc: articles
Pubmed: articles
Ncbi: proteins

via Wikipedia infobox

Wikidata facts

Subclass of: transaminase
Image: Aspartate transaminase.png

Show 2 more facts

EC enzyme number: 2.6.1.1
Commons category: Aspartate transaminases

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954. AST catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver, heart, skeletal muscle, kidneys, brain, red blood cells and gall bladder. Serum AST level, serum ALT (alanine transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.

The half-life of total AST in the circulation approximates 17 hours and, on average, 87 hours for mitochondrial AST. Aminotransferase is cleared by sinusoidal cells in the liver.

Excerpted from Wikipedia’s “aspartate transaminase” article, available under the CC BY-SA 4.0 licence.