aldosterone

Also known as (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al, (+)-aldosterone, delta-Aldosterone, 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione, Aldocorten, Reichstein X, 11-Hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde, 18-Oxocorticosterone

ormone surrenale

OverviewAI-generated

Aldosterone is a chemical compound with the formula C₂₁H₂₈O₅. Its molecular mass is listed as 360.194, while its weight is recorded as 360.4. The substance has a charge of 0 and an xlogp value of 1.1.

Structural data for aldosterone includes a topological polar surface area of 91.7. The molecule contains two hydrogen bond donors and five hydrogen bond acceptors. Specific structural representations are provided through canonical and isomeric SMILES strings.

The compound is associated with a large body of literature, with 56,813 entries found in PubMed. Additionally, it is referenced by 1,286 other encyclopedia articles.

Synthesized by Vinony from 17 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Chemical data

Formula: C21H28O5
Molecular weight: 360.4 g/mol
IUPAC name: (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
InChIKey: PQSUYGKTWSAVDQ-ZVIOFETBSA-N
XLogP: 1.1
Polar surface area: 91.7 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

56,813 papers

Primary Aldosteronism, Aldosterone, and Extracellular Vesicles.ReviewEndocrinology · 2022Carvajal CA, Tapia-Castillo A, Pérez JA et al.DOI: 10.1210/endocr/bqab240
Diagnosis and treatment of primary aldosteronism.ReviewThe lancet. Diabetes & endocrinology · 2021Reincke M, Bancos I, Mulatero P et al.DOI: 10.1016/S2213-8587(21)00210-2
Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism.ReviewExperimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2019Schilbach K, Junnila RK, Bidlingmaier MDOI: 10.1055/a-0672-0836
Overview of aldosterone-related genetic syndromes and recent advances.ReviewCurrent opinion in endocrinology, diabetes, and obesity · 2018Zennaro MC, Fernandes-Rosa FL, Boulkroun SDOI: 10.1097/MED.0000000000000409
Aldosterone-Producing Adenomas.Vitamins and hormones · 2019Hellman P, Björklund P, Åkerström TDOI: 10.1016/bs.vh.2018.10.007
Primary aldosteronism - a multidimensional syndrome.ReviewNature reviews. Endocrinology · 2022Turcu AF, Yang J, Vaidya ADOI: 10.1038/s41574-022-00730-2
Aldosterone and aldosteronism.ReviewSteroids · 2003Horton RDOI: 10.1016/j.steroids.2003.09.006
Aldosterone receptor antagonists: current perspectives and therapies.ReviewVascular health and risk management · 2013Guichard JL, Clark D 3rd, Calhoun DA et al.DOI: 10.2147/VHRM.S33759

via PubMed

Wikidata facts

Has part: carbon
Mass: 360.194

Show 8 more facts

chemical formula: C₂₁H₂₈O₅
canonical SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
found in taxon: Homo sapiens
Commons category: Aldosterone
physically interacts with: Nuclear receptor subfamily 3 group C member 2
produced by: zona glomerulosa
subject has role: primary metabolite

Sources (8)

via Wikidata · CC0

Article · Italiano

L'aldosterone è un ormone steroideo prodotto dalla zona glomerulare della corticale del surrene, è detto sodio ritentivo e potassio espulsivo per la sua azione sui due ioni. È il capostipite degli ormoni mineralcorticoidi che, come i glucocorticoidi, vengono prodotti nella corteccia del surrene, ma attraverso due vie biosintetiche distinte. A differenza del glucocorticoide cortisolo, il controllo della sintesi non dipende principalmente dalla tropina adenoipofisiaria ACTH: infatti, liberazione di aldosterone nell'organismo dipende da diversi fattori, i più importanti dei quali sono l'aumento della concentrazione extracellulare di potassio che agisce direttamente sulla corteccia surrenale e l'attivazione del sistema renina-angiotensina-aldosterone per riduzione della pressione arteriosa (la riduzione della pressione attiva il sistema renina-angiotensina-aldosterone che serve a farla aumentare di nuovo).

Abstract from DBpedia / Wikipedia · CC BY-SA