enoxolone
Sign in to saveEnoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
Key facts
- Drug.IUPAC_name
- (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
- Drug.image
- Glycyrrhetinic acid structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.tradename
- Arthrodont, PruClair
- Drug.legal_US
- Rx-only
- Drug.routes_of_administration
- Oral, topical
- Drug.CAS_number
- 471-53-4
- Drug.UNII
- P540XA09DR
- Drug.ATC_prefix
- D03
- Drug.ATC_suffix
- AX10
- Drug.PubChem
- 10114
- Drug.DrugBank
- DB13089
- Drug.ChemSpiderID
- 9710
- Drug.KEGG
- D00156
- Drug.ChEBI
- 30853
- Drug.ChEMBL
- 230006
- Drug.C
- 30
via Wikipedia infobox
Research
4,077 papers- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial.Frontiers in immunology · 2023
- Liquorice and hypertension.The Netherlands journal of medicine · 2005
- Sensitization to oral enoxolone.Contact dermatitis · 1994
- OCULAR DISCOMFORT IN PROFESSIONAL POLO-WATER PLAYERS: A PRACTICAL EXPERIENCE WITH TOPICAL HYALURONIC ACID AND GLYCURONATE ENOXOLONE.Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti · 2023
- [Pseudoaldosteronism].Ryoikibetsu shokogun shirizu · 1997
via PubMed
Article
12 sectionsContents
- Medical uses
- Oral topical
- Skin topical
- Possible other uses
- Mechanism of action
- Anti-inflammatory
- Hypertensive
- Derivatives
- See also
- References
- Further reading
- External links
Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
The substance has a sweet taste, so it is used in flavoring to mask the bitter taste of drugs like aloe and quinine. It may have some anti-inflammatory activities. One of its metabolites is responsible for the blood pressure-increasing effect of liquorice.