anisomycin
Sign in to saveAlso known as 2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate, 1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate
Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
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Encyclopedic overview
5 sectionsContents
- Pharmacology
- Biosynthesis
- Other uses
- See also
- References
Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
==Pharmacology== Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Excerpted from Wikipedia’s “anisomycin” article, available under the CC BY-SA 4.0 licence.