floxuridine
Sign in to saveFloxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. Specifically, floxuridine is a pyrimidine analog, classified as a deoxyuridine. The drug is usually administered via an artery, and most often used in the treatment of colorectal cancer. The quality of life and survival rates of individuals that receive continuous hepatic artery infusion of floxuridine for colorectal cancer metastases is significantly higher than control groups. Floxuridine can also be prescribed for the treatment of kidney and stomach cancers. In vitro uses of floxu
Research
3,715 papers- Floxuridine Oligomers Activated under Hypoxic Environment.Journal of the American Chemical Society · 2021
- Esterase-Responsive Floxuridine-Tethered Multifunctional Nanoparticles for Targeted Cancer Therapy.ACS applied bio materials · 2024
- The role of floxuridine in metastatic liver disease.Molecular cancer therapeutics · 2009
- Reduced Floxuridine Dose Limits Hepatobiliary Toxicity Without Negatively Impacting Survival After Resection of Colorectal Cancer Liver Metastases.Annals of surgical oncology · 2025
- Evaluating the Antibacterial and Antivirulence Activities of Floxuridine against Streptococcus suis.International journal of molecular sciences · 2023
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Article
15 sectionsContents
- Biosynthesis
- Pharmacology
- Pharmacodynamics
- Mechanism of action
- Route of elimination
- Side effects
- Common (30% of patients)
- Less common (10–29% of patients)
- Contact your health provider immediately
- Contact your health provider
- Other
- Use in research
- History
- Alternative names
- References
Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. Specifically, floxuridine is a pyrimidine analog, classified as a deoxyuridine. The drug is usually administered via an artery, and most often used in the treatment of colorectal cancer. The quality of life and survival rates of individuals that receive continuous hepatic artery infusion of floxuridine for colorectal cancer metastases is significantly higher than control groups. Floxuridine can also be prescribed for the treatment of kidney and stomach cancers. In vitro uses of floxuridine include 5-minute treatments of fluorouracil, floxuridine, and mitomycin to increase cell proliferation in Tenon's capsule fibroblasts.
==Biosynthesis == thumb|400px|Biosynthesis of floxuridine Immobilized Aeromonas salmonicida ATCC 27013, when exposed to thymidine and 5-fluorouracil in phosphate buffer at room temperature for one hour, can synthesize floxuridine and thymine.