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belzutifan

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belzutifan

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Also known as 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Welireg

Belzutifan, sold under the brand name Welireg, is an anti-cancer medication used for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. It is taken by mouth. Belzutifan is an hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor.

Key facts

Drug.MedlinePlus
a621047
Drug.DailyMedID
Belzutifan
Drug.pregnancy_AU
D
Drug.image
Belzutifan.svg
Drug.image_class
skin-invert-image
Drug.tradename
Welireg
Drug.routes_of_administration
By mouth
Drug.class
Antineoplastic
Drug.ATC_prefix
L01
Drug.ATC_suffix
XX74
Drug.legal_AU
S4
Drug.legal_CA
Rx-only
Drug.legal_UK
POM
Drug.legal_US
Rx-only
Drug.legal_EU
Rx-only
Drug.CAS_number
1672668-24-4
Drug.PubChem
117947097
Drug.DrugBank
DB15463

via Wikipedia infobox

Chemical data

Formula
C17H12F3NO4S
Molecular weight
383.3 g/mol
IUPAC name
3-[[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]-5-fluorobenzonitrile

via PubChem

Wikidata facts

Mass
383.044
Show 6 more facts
isomeric SMILES
CS(=O)(=O)C1=C2[C@@H]([C@@H]([C@@H](C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O
chemical formula
C₁₇H₁₂F₃NO₄S
canonical SMILES
CS(=O)(=O)C1=C2C(C(C(C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O
medical condition treated
von Hippel-Lindau disease
Commons category
Belzutifan
legal status (medicine)
boxed warning
Sources (4)

via Wikidata · CC0

~8 min read

Encyclopedic overview

8 sections
Contents
  • Medical uses
  • Adverse effects
  • History
  • Society and culture
  • Legal status
  • See also
  • References
  • External links

{{Infobox drug | image = Belzutifan.svg | image_class = skin-invert-image | width = | alt = | caption =

| pronounce = | tradename = Welireg | Drugs.com = | MedlinePlus = a621047 | DailyMedID = Belzutifan | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Antineoplastic | ATC_prefix = L01 | ATC_suffix = XX74 | ATC_supplemental =

Excerpted from Wikipedia’s “belzutifan” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0