apolipoprotein(a)
Sign in to saveAlso known as lipoprotein(a), lipoprotein (a)
Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke.
Protein · UniProt
Apolipoprotein(a)
- Gene
- LPA
- Organism
- Homo sapiens (Human)
- Length
- 2,040 aa
- Molecular mass
- 226,546 Da
- Evidence
- 1: Evidence at protein level
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330
Swiss-Prot (reviewed) · via UniProt
Research
18,151 papers- Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods.International journal of molecular sciences · 2023
- Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.Lancet (London, England) · 2016
- Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: Where Do We Stand?International journal of molecular sciences · 2024
- Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial.JAMA · 2023
- Apolipoprotein(a) Kinetics in Statin-Treated Patients With Elevated Plasma Lipoprotein(a) Concentration.The Journal of clinical endocrinology and metabolism · 2019
via PubMed
Clinical Trials
67 registered- PHASE3COMPLETEDBapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)JANSSEN Alzheimer Immunotherapy Research & Development, LLC · NCT00574132
- UNKNOWNSRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic OutcomesUniversity of Toronto · NCT05637866
- PHASE3COMPLETEDStudy to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial HypercholesterolemiaKastle Therapeutics, LLC · NCT00607373
- NACOMPLETEDA Study to Evaluate Fasting/Postprandial Serum Apolipoprotein B-48 (ApoB-48) Levels in Diabetic Participants With Normal to Moderately High Low Density Lipoprotein-C (LDL-C) Levels (MK-0653A-259 AM1)Organon and Co · NCT01333436
- COMPLETEDThe Association of SAA With Apolipoprotein B Affects Cardiovascular RiskLisa Tannock · NCT02770872
- UNKNOWNLipoprotein and Apolipoproteins With Metabolic Liver DiseasesChun-Hsiang Wang · NCT03220971
~14 min read
Encyclopedic overview
12 sectionsContents
- Structure
- Populations
- Function and pathology
- Catabolism and clearance
- Disease
- Diagnostic testing
- Treatment
- Clinical trials
- Interactions
- See also
- References
- External links
Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke.
Lipoprotein(a) was discovered in 1963 by Kåre Berg. The human gene encoding apolipoprotein(a) was successfully cloned in 1987.
Excerpted from Wikipedia’s “apolipoprotein(a)” article, available under the CC BY-SA 4.0 licence.